Applies to all Barracuda SSL VPNs.
In the Skype options under Advanced > Connection there is an option labeled Use port 80 and 443 as alternatives for incoming connections. This is enabled by default. This option can interfere with any Host File Redirect Tunneled Web Forwards that are set to use either of these ports as the client will not be able to open the tunnel on the required port.
The best way to resolve this issue is to disable the option in Skype and ensure the port option is set to something that will not interfere with the Web Forwards.
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