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Microsoft Azure Restrictions and Limitations

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If you are running Barracuda Email Security Gateway on Microsoft Azure, Microsoft imposes certain restrictions and limitations. At this time, Microsoft supports sending outbound mail from the Barracuda Email Security Gateway on Microsoft Azure to Office 365 (O365) via port 587 if you want to use O365 to relay email on behalf of the Barracuda Email Security Gateway in Azure.
See the Microsoft Support article Microsoft server software support for Microsoft Azure virtual machines for more information on restrictions and limitations.
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